Inhibiting Tissue Angiotensin-Converting Enzyme

Angiotensin Converting Enzyme in Sarcoidosis

Role of Tissue Angiotensin-Converting Enzyme Inhibition

Background Chronic treatment with high doses of angiotensin-converting enzyme (ACE) inhibitors prolongs survival after myocardial infarction. Since the plasma reninangiotensin system (RAS) is not consistently activated in the chronic phase after myocardial infarction, the beneficial effects of ACE inhibition have been attributed, in part, to inhibition of an activated tissue RAS. However, a rel...

angiotensin converting enzyme in sarcoidosis

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Inhibiting tissue angiotensin-converting enzyme: a pound of flesh without the blood?

Angiotensin-converting enzyme catalyzes the formation of angiotensin II (Ang II) from Ang I but also degrades bradykinin (BK). Ang II, acting through the AT1 receptor, is a potent vasoconstrictor, stimulates norepinephrine release from sympathetic nerve terminals in the heart, and causes hypertrophy of cardiac myocytes. BK, via activation of the BK2 receptor, stimulates the release of NO and pr...

Serum Angiotensin Converting Enzyme in Patients with Psoriasis

Background: Controversial data concerning the elevation of serum angiotensin-converting enzyme in psoriasis are reported in the literature. In order to verify whether this abnormality exists in Iranian patients, we performed this study. Method: Serum angiotensin-converting enzyme level was measured in 40 psoriatics. According to clinical forms of psoriasis, patients were further divided into th...